Monday, June 02, 2014

The Cure Is Worse Than The Malady

Need an antidepressant?

Stay the hell away from Anafranil (clomipramine).

I'm going to list this first because some Constant Readers are TL;DRs-

Genitourinary Effects-

Decreased nocturnal penile tumescence and delayed ejaculation have been reported.
Cases of spontaneous orgasm associated with yawning and clomipramine (the active ingredient contained in Anafranil) therapy have been reported.
Genitourinary side effects have been reported frequently and have included sexual dysfunction (involving anorgasmia, impotence and decreased libido). Urinary retention has also been reported.
Spontaneous orgasm due to yawning? Are you kidding me? Don't take this stuff on Sunday morning before heading off to church, Jocko.

Yeah- it'll ease your depression, but at what cost?

From the listed side effects at

More common effects:  (Emphasis mine)
  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • congestion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cough
  • difficult, burning, or painful urination
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dryness or soreness of the throat
  • excessive muscle tone
  • fear or nervousness
  • feeling sad or empty - I thought this stuff was supposed to prevent this?
  • fever
  • frequent urge to urinate
  • hearing loss
  • hoarseness
  • irritability
  • lack of appetite
  • loss of interest or pleasure -  Same as above.
  • lower back or side pain
  • muscle stiffness
  • muscle tension or tightness
  • muscle twitching or jerking
  • pain or tenderness around the eyes and cheekbones
  • poor concentration
  • problems in urination or increase in the amount of urine
  • rhythmic movement of muscles
  • runny nose
  • shortness of breath or troubled breathing
  • sneezing
  • stuffy nose
  • sweating
  • tender, swollen glands in the neck
  • tightness of the chest or wheezing
  • tiredness
  • trouble concentrating
  • trouble remembering
  • trouble sleeping
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
Less common effects:

  • Anger that is hard to control
  • anxiety
  • bloody nose
  • breast enlargement
  • burning, dry, or itching eyes
  • burning while urinating
  • changes in vision
  • chills
  • crying
  • decrease in the frequency of urination
  • decrease in urine volume
  • depersonalization
  • difficulty in passing urine (dribbling)
  • difficulty in speaking
  • discharge or excessive tearing
  • dry mouth
  • dysphoria
  • earache
  • euphoria
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of unreality
  • headache, severe and throbbing
  • hyperventilation
  • increased clear or white vaginal discharge
  • increased watering of the mouth
  • irregular heartbeats
  • irritability
  • itching of the vagina or genital area
  • mental depression
  • nausea or vomiting
  • numbness, tingling, pain, or weakness in the hands or feet
  • pain during sexual intercourse
  • pale skin
  • panic attacks
  • paranoia
  • partial or slight paralysis
  • quick to react or overreact emotionally
  • rapidly changing moods
  • redness or swelling in the ear
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • restlessness
  • sense of detachment from self or body
  • shaking
  • swelling of the face, fingers, feet, or lower legs
  • thick, white vaginal discharge with no odor or with a mild odor
  • troubled breathing with exertion
  • unusual bleeding or bruising

Some other side effects of clomipramine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common:
  • Acid or sour stomach
  • bad, unusual, or unpleasant aftertaste
  • belching
  • blemishes on the skin
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloated
  • change in taste
  • change or problem with discharge of semen
  • changes in vision
  • constipation
  • cracked, dry, or scaly skin
  • cramps
  • darkening or lightening of skin color
  • decreased interest in sexual intercourse
  • diarrhea
  • difficulty with moving
  • dry skin
  • excess air or gas in the stomach or intestines
  • feeling of warmth
  • full feeling
  • heartburn
  • heavy bleeding
  • hives or welts
  • inability to have or keep an erection
  • increased appetite
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • indigestion
  • joint pain
  • loss in sexual ability, desire, drive, or performance
  • pain
  • passing gas
  • pimples
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin
  • shakiness in the legs, arms, hands, or feet
  • skin rash
  • stomach discomfort, upset, or pain
  • swelling
  • swollen joints
  • trembling or shaking of the hands or feet
Less common:
  • Absent, missed, or irregular menstrual periods
  • breast pain
  • increased yawning
  • pinpoint red or purple spots on the skin
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stopping of menstrual bleeding

Oh HELLS no!

I'll just stick with my regular depression...
Rum & Coke with a twist of lime (to prevent scurvy)

Screw modern medicine- that shit will kill you.



kx59 said...

I'm with you.
I'm having a Tito's and tonic with a slice of fresh orange...for medicinal purposes of course.

Old NFO said...

YGTBSM... Scotch over here please!

kx59 said...

I an not objectionable to a fine well aged scotch either.
I find it to be quite refined. :-)

Midwest Chick said...

It's easing your depression because you can have an orgasm when you yawn.

*When You Yawn!*

Some folks would put up with the rest just to be able to do THAT.

The Big Guy said...

"Oh baby... Tell me another boring story! You're soooo mundane!"

Midwest Chick said...

@TBG--"Hey sweetie, you go ahead and go out. I'm going to stay in and watch paint dry while listening to elevator music. I'll be fine... really!"